Brain Drain is a puzzle video game for Nintendo Wii developed and published by Enjoy Gaming.

In the game, place the elements of a scrambled puzzle according to a given model. Select elements with your game cursor and spin them to move elements in the puzzle area. Some puzzles may feature malicious game effects that will slow you down during your puzzle solving. There are three game modes to choose from: Challenge (200 fixed puzzles with preset best times to solve and beat), Race (a stream of puzzles and best-time tables to beat in four difficulty levels) and Random (relaxed, random puzzling that continues endlessly).

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